While whole plant medicine certainly provides the benefits
of the Entourage Effect, isolated cannabinoids may lead to what we at Cleveland
Botanical Destination refer to as personalized cannabinoid medicine.
Cannabinoid isolation and reformulation for individual patient needs may be the
path to the future. Much or current research is working diligently to uncover
these minor cannabinoids for what is likely to be the next big movement in
cannabinoid supplements and medicines.
CBN is one of the minors we are focusing on to supplement alongside
CBD products. The reason why CBN is gaining momentum is because it works well
with CBD for sleep formulations.
CBN, or cannabinol, is one of the many cannabinoids that
science is beginning to illuminate the potential. A report from the cannabis
testing facility Steep Hill Labs claims that 2.5-5 milligrams of CBN are as
effective as 5-10 milligrams of Valium or diazepam. They purport it is the most
effective cannabinoid as a sleep aid. To further CBN as a top Thanksgiving
herb, a study conducted on lab rats published in 2012 found that CBN acted as
an appetite stimulant while CBD acted as an appetite suppressant.
The process of creating CBN can be simple…wait. THC
naturally found in cannabis degrades into CBN. This fact makes it relatively
unique, as the basis for all known cannabinoids is CBGa or cannabigerolic acid.
CBGa then is further produced into the acid forms of the other cannabinoids,
namely THCa, CBDa, and CBCa.
WHAT WE KNOW ABOUT CBN
CBNa, which is the acidic form of CBN, is a byproduct of the
aging of THCa. It is also produced when cannabis is exposed to heat, oxygen, or
UV lighting. CBN is naturally found with about 1% concentration in various
strains, which means it’s not the most abundantly available cannabinoid,
although levels do change with heat and light exposure.
Although THC and CBD are much more popular, CBN was first
successfully isolated in the 1930s. While CBD is a non-psychoactive substance,
CBN is a slightly psychoactive substance. Although CBN was initially thought to
be the cannabinoid responsible for the psychoactive effects of cannabis, it is
estimated to be only about 10% as powerful as THC.
CBN has occasionally been painted as a black sheep
cannabinoid, as it is most densely located in aged cannabis. Although CBN is
degraded THC, it is not necessarily an inferior THC. It is a unique
cannabinoid, more similar in potency to CBD than THC. Although the earliest
discovered cannabinoid, research available on CBN, is disappointingly lacking.
Still, with the research available, CBN has shown great medical potential as a:
Potent Sedative – Sleeping issues can be associated with
several ailments, such as PTSD, eating disorders, or mood-affective disorders.
A study from 1995 conducted on mice found that CBN worked to increase sleep
time. Likewise, a more recent study published in early 2019 by Kanabo Research
shows CBN works very well when combined with a formulation of other
cannabinoids.
Anti-Glaucoma - Similar to ?-9-THC, CBN reduces intraocular
pressure in the eye so it can be used to treat Glaucoma for the same reason
?-9-THC can be used, although CBN has very mild to no psychoactive effects.
This was found by a 1984 study on cats with glaucoma, revealing that chronic
use caused a reduction in intraocular tension.
Appetite-Stimulant - A 2012 study suggests that CBN had a
stimulating influence on the appetite of lab rats, while CBD has the opposite
effect. Loss of appetite affects thousands of people yearly, whether as a
symptom of a physical or psychic condition.
Anti-Bacterial - CBN has shown the potential to be effective
in fighting against MRSA bacteria, an antibiotic-resistant strain.
Pain-Relief - Research has revealed that the way CBN
interacts with the pain signals sent in the brain can help with pain mana THC-Free
CBN Isolate Health and Wellness Benefits
Increasing interest in CBN isolate that is hemp derived has
steadily grown as demonstrated by the rapidly expanding number of publications
and patent disclosures.
While whole plant medicine certainly provides the benefits
of the Entourage Effect, isolated cannabinoids may lead to what we at Cleveland
Botanical Destination refer to as personalized cannabinoid medicine.
Cannabinoid isolation and reformulation for individual patient needs may be the
path to the future. Much or current research is working diligently to uncover
these minor cannabinoids for what is likely to be the next big movement in
cannabinoid supplements and medicines.
CBN is one of the minors we are focusing on to supplement alongside
CBD products. The reason why CBN is gaining momentum is because it works well
with CBD for sleep formulations.
CBN, or cannabinol, is one of the many cannabinoids that
science is beginning to illuminate the potential. A report from the cannabis
testing facility Steep Hill Labs claims that 2.5-5 milligrams of CBN are as
effective as 5-10 milligrams of Valium or diazepam. They purport it is the most
effective cannabinoid as a sleep aid. To further CBN as a top Thanksgiving
herb, a study conducted on lab rats published in 2012 found that CBN acted as
an appetite stimulant while CBD acted as an appetite suppressant.
The process of creating CBN can be simple…wait. THC
naturally found in cannabis degrades into CBN. This fact makes it relatively
unique, as the basis for all known cannabinoids is CBGa or cannabigerolic acid.
CBGa then is further produced into the acid forms of the other cannabinoids,
namely THCa, CBDa, and CBCa.
WHAT WE KNOW ABOUT CBN
CBNa, which is the acidic form of CBN, is a byproduct of the
aging of THCa. It is also produced when cannabis is exposed to heat, oxygen, or
UV lighting. CBN is naturally found with about 1% concentration in various
strains, which means it’s not the most abundantly available cannabinoid,
although levels do change with heat and light exposure.
Although THC and CBD are much more popular, CBN was first
successfully isolated in the 1930s. While CBD is a non-psychoactive substance,
CBN is a slightly psychoactive substance. Although CBN was initially thought to
be the cannabinoid responsible for the psychoactive effects of cannabis, it is
estimated to be only about 10% as powerful as THC.
CBN has occasionally been painted as a black sheep
cannabinoid, as it is most densely located in aged cannabis. Although CBN is
degraded THC, it is not necessarily an inferior THC. It is a unique
cannabinoid, more similar in potency to CBD than THC. Although the earliest
discovered cannabinoid, research available on CBN, is disappointingly lacking.
Still, with the research available, CBN has shown great medical potential as a:
Potent Sedative – Sleeping issues can be associated with
several ailments, such as PTSD, eating disorders, or mood-affective disorders.
A study from 1995 conducted on mice found that CBN worked to increase sleep
time. Likewise, a more recent study published in early 2019 by Kanabo Research
shows CBN works very well when combined with a formulation of other
cannabinoids.
Anti-Glaucoma - Similar to ?-9-THC, CBN reduces intraocular
pressure in the eye so it can be used to treat Glaucoma for the same reason
?-9-THC can be used, although CBN has very mild to no psychoactive effects.
This was found by a 1984 study on cats with glaucoma, revealing that chronic
use caused a reduction in intraocular tension.
Appetite-Stimulant - A 2012 study suggests that CBN had a
stimulating influence on the appetite of lab rats, while CBD has the opposite
effect. Loss of appetite affects thousands of people yearly, whether as a
symptom of a physical or psychic condition.
Anti-Bacterial - CBN has shown the potential to be effective
in fighting against MRSA bacteria, an antibiotic-resistant strain.
Pain-Relief - Research has revealed that the way CBN
interacts with the pain signals sent in the brain can help with pain mana THC-Free
CBN Isolate Health and Wellness Benefits
Increasing interest in CBN isolate that is hemp derived has
steadily grown as demonstrated by the rapidly expanding number of publications
and patent disclosures.