While CBD and CBDA are chemically similar, they are not interchangeable.
CBDA doesn’t act directly on the endocannabinoid system. Instead, by inhibiting COX-2 activity, it has an indirect effect. It also acts on 5-HT receptors, which influence serotonin production. Serotonin production is essential to overall health, including reduced anxiety and general well-being.
When considering your cannabinoid options, it’s not quite fair to say that one cannabinoid is superior to the other, they each have unique potential. Each of the many plant elements in our products works together synergistically to enhance the effects of the other.
Compatibility: CBD has the potential to boost CBDA's potential benefits!
Taste: Concentrated CBDA tastes a little bitter. When blended with CBD it tends to mitigate the taste of CBDA.
Typical FAQ’s About The Benefits of CBDA
Question: Is CBDA better than CBD?
Answer: As of now there is still no concrete proof that CBDA is better than CBD, although there are claims that CBDA is more potent than CBD
Question: Can CBDA also function as a potent anti-inflammatory drug?
Answer: Yes. Like CBD, CBDA can be also a potent anti-inflammatory drug
Question: What's the difference between CBDA and CBD?
Answer: One of the main differences is that CBDA contains a COOH chemical group called a carboxyl group. Decarboxylation removes the carboxyl group and thus leaving only CBD
Question: What are the benefits of CBDA?
Answer: Some of the benefits of CBDA include reduce nausea and vomiting, relieves pain, an anti-depressant, and lower stress and anxiety.
Question: How can you consume CBDA?
Answer: You can ingest CBDA in any form. Using a tincture and dosing under the tongue is the best administration method.
Researchers noticed that CBDA had a very similar structure to commonly used non-steroidal anti-inflammatory drugs (NSAIDs). This class of drugs includes everyday painkillers such as acetaminophen and ibuprofen. These researchers followed up on their discoveries by investigating whether CBDA actually worked the same way as common NSAIDs. Amazingly, they found that CBDA inhibits COX-2, the same body chemical that’s inhibited by NSAIDs.
However, CBDA isn’t just used to reduce inflammation. It can also be used to treat nausea and anxiety. In this case, there’s a strong similarity between CBDA vs CBD. In fact, CBDA is actually more effective. It’s more than a thousand times more effective than CBD in activating a serotonin receptor that reduces nausea and anxiety. This effect is even more pronounced in chemotherapy patients who are using ondansetron (OND) to treat nausea. Overall, CBDA could help alleviate inflammation and pain, symptoms of depression, nausea and vomiting, seizures, and convulsions.
Inflammation and Pain Relief
One of CBDA’s potential therapeutic powers is that it might help relieve inflammation and associated pain. As mentioned earlier, CBDA works by interacting with enzymes and receptors. In this case, CBDA may help relieve inflammation by inhibiting the cyclooxygenase-2 (COX-2) enzyme. This enzyme is associated with inflammation after infection or injury. By blocking COX-2 enzymes, this cannabinoid may help relieve inflammation and pain. One study proved that CBDA was more effective than THC at decreasing the expression of the COX-2 enzyme.
In a recent study, researchers exploring the anti-inflammatory properties of CBDA looked at the molecular structures of CBDA and nonsteroidal anti-inflammatory drugs (NSAIDs), which are common in the treatment of inflammation. They found that the molecular structures were incredibly similar. It was therefore concluded that CBDA could potentially be used as an anti-inflammatory agent.
Nausea and Vomiting
In a rodent study, researchers found that CBDA affected serotonin levels, which is a neurotransmitter that helps in signaling between cells. Serotonin also comes in handy in regulating various bodily functions like eating, motor skills, emotions, and digestion. Researchers discovered that the levels of serotonin are often affected by various stressors, including radiation and chemotherapy.
Particularly, it was found that chemotherapy and radiation caused the body to release excess serotonin, which, in turn, induced nausea and vomiting. Many cancer patients experience chemotherapy-induced nausea and vomiting, and some even find it hard to put up with this form of treatment. While vomiting can be dealt with through medication, nausea proves to be more distressing and hard to control since it is a continuous sensation.
Thanks to the potential of CBDA to influence the activity of 5-HT serotonin-producing receptors, medical practitioners believe that CBDA may be used as a way to manage chemotherapy-induced nausea and vomiting. While this is a subject that needs more research, it hints at how helpful CBDA may be to cancer patients receiving chemotherapy treatment.
Seizures and Convulsions
The interaction of CBDA and the 5-HT receptors makes this cannabinoid a potentially powerful anticonvulsive. Compared to CBD, scientists have found that CBDA has up to 100 times the affinity of these receptors. This means that CBDA can interact more easily with these receptors than CBD, and can be metabolized faster and in less time.
Breast Cancer Treatment
While the research on CBDA and cancer has only been done on isolated cells, there has been an indication that CBDA can potentially stop metastasis, especially with an aggressive form of breast cancer cell called MDA-MB-231. However, more research is required to determine how CBDA can stop or prevent cancer cells’ migration.
Anxiety and Depression
The interaction of CBDA and the 5-HT receptors is responsible for the various potential benefits of CBDA in the body. The affinity of this cannabinoid for these receptors could make it a potential remedy for symptoms of anxiety and depression. Serotonin is a monoamine neurotransmitter whose biological function in the human body is multifaceted and complex. It regulates various physiological processes in the body, including modulating mood.
Serotonin is often referred to as the happy chemical as it contributes to happiness and well-being. Over the years, scientists have considered depression to be a result of hormone and neurotransmitter imbalance. Depression has also been linked with low serotonin levels, but whether this is the major cause remains unanswered. Studies have suggested that CBDA might interact with the 5-HT receptors in the same way as antidepressant medication, or selective serotonin reuptake inhibitors (SSRIs). This way, CBDA is thought to show promise for symptoms of depression.
Other Potential Benefits of CBDA
Apart from the benefits highlighted above, CBDA has potential anti-bacterial, anti-oxidant, and analgesic properties. These properties could make this cannabinoid a great remedy for various conditions, including auto-immune conditions. From direct work with clients CBDA works very well for individuals with ADHD and Autism diagnosis.